Expression of pendrin and NIS iodide transporters in human breast tumor and peri-tumoral tissue
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چکیده
منابع مشابه
Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid.
Thyroid hormones are essential for normal development and metabolism. Thyroid hormone biosynthesis requires iodide uptake into the thyrocytes and efflux into the follicular lumen, where it is organified on selected tyrosyls of thyroglobulin. Uptake of iodide into the thyrocytes is mediated by an intrinsic membrane glycoprotein, the sodium-iodide symporter (NIS), which actively cotransports two ...
متن کاملThe Sodium Iodide Symporter (NIS) and Potential Regulators in Normal, Benign and Malignant Human Breast Tissue
INTRODUCTION The presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators in human breast tissue, with relationships observed further investigated in vitro. METHODS Human breast tissue specimens (malignant n = 75, normal n = 15, fibroadenoma n = 10)...
متن کاملPendrin and sodium/iodide symporter protein expression in the testicular tissue of normal and diabetic rats in prepubertal and post pubertal stages
Pendrin (PDS) and sodium/iodide symporter (NIS) are transmembrane proteins that are located in numerous tissue types, particularly thyroid follicular epithelial cells, where they are entrusted with the regulation of iodine molecules. In the present study, we aimed to clarify changes in PDS and NIS protein expression, in the testicular tissue of prepubertal and <span la...
متن کاملAbsence of Human Papillomavirus in Benign and Malignant Breast Tissue
Background & Objective: Malignant breast tumors, which are one of the most important deadly cancers in women, like many other cancers, are proposed to be related to viruses etiologically. Proper management of breast carcinoma necessitates an identification of the etiological factors. Human Papillomavirus is considered to have an etiological role in breast carcinoma. We...
متن کامل(NIS)-Mediated Iodide Transport in Breast Cancer Cells Hydrocortisone and Purinergic Signaling Stimulate Sodium/Iodide Symporter
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ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2019
ISSN: 1734-1922,1896-9151
DOI: 10.5114/aoms.2019.89980